USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: PSA4_HUMAN USC-OGP 2-DE database:  PSA4_HUMAN PSA4_HUMAN General information about the entry View entry in simple text format Entry name PSA4_HUMAN Primary accession number P25789 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Proteasome subunit alpha type-4; EC=3.4.25.1 {ECO:0000269|PubMed:27176742}; AltName: Full=Macropain subunit C9; AltName: Full=Multicatalytic endopeptidase complex subunit C9; AltName: Full=Proteasome component C9; AltName: Full=Proteasome subunit L;. Gene name Name=PSMA4 Synonyms=HC9, PSC9 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1270: pI=6.97; Mw=28628 Cross-references UniProtKB/Swiss-Prot P25789; PSA4_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PSA4_HUMAN Primary accession number P25789 Secondary accession number(s) D3DW86 Q53XP2 Q567Q5 Q8TBD1 Sequence was last modified on  May 1, 1992 (version 1) Annotations were last modified on  March 15, 2017 (version 184) Name and origin of the protein Description RecName: Full=Proteasome subunit alpha type-4; EC=3.4.25.1 {ECO:0000269|PubMed:27176742}; AltName: Full=Macropain subunit C9; AltName: Full=Multicatalytic endopeptidase complex subunit C9; AltName: Full=Proteasome component C9; AltName: Full=Proteasome subunit L; Gene name Name=PSMA4 Synonyms=HC9, PSC9 Encoded on Name=PSMA4; Synonyms=HC9, PSC9 Keywords 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Hydrolase; Nucleus; Phosphoprotein; Protease; Proteasome; Reference proteome; Threonine protease. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL D00763; BAA00660.1; -; mRNA EMBL BT009784; AAP88786.1; -; mRNA EMBL AC027228; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471136; EAW99163.1; -; Genomic_DNA EMBL CH471136; EAW99164.1; -; Genomic_DNA EMBL BC005361; AAH05361.1; -; mRNA EMBL BC022445; AAH22445.1; -; mRNA EMBL BC022817; AAH22817.2; -; mRNA EMBL BC047667; AAH47667.1; -; mRNA EMBL BC093069; AAH93069.1; -; mRNA CCDS CCDS10303.1; -. [P25789-1]; . CCDS CCDS45319.1; -. [P25789-2]; . PIR S15972; SNHUC9; . RefSeq NP_001096137.1; NM_001102667.2. [P25789-1]; . RefSeq NP_001096138.1; NM_001102668.2. [P25789-2]; . RefSeq NP_001317605.1; NM_001330676.1. [P25789-1]; . RefSeq NP_002780.1; NM_002789.5. [P25789-1]; . UniGene Hs.251531; -; . PDB 4R3O; X-ray; 2.60 A; C/Q=2-251 PDB 4R67; X-ray; 2.89 A; C/Q/e/s=2-251 PDB 5A0Q; EM; 3.50 A; C/Q=1-261 PDB 5GJQ; EM; 4.50 A; D/j=1-261 PDB 5GJR; EM; 3.50 A; D/j=1-261 PDB 5L4G; EM; 4.02 A; C/P=1-261 PDB 5LE5; X-ray; 1.80 A; B/P=1-261 PDB 5LEX; X-ray; 2.20 A; B/P=1-261 PDB 5LEY; X-ray; 1.90 A; B/P=1-261 PDB 5LEZ; X-ray; 2.19 A; B/P=1-261 PDB 5LF0; X-ray; 2.41 A; B/P=1-261 PDB 5LF1; X-ray; 2.00 A; B/P=1-261 PDB 5LF3; X-ray; 2.10 A; B/P=1-261 PDB 5LF4; X-ray; 1.99 A; B/P=1-261 PDB 5LF6; X-ray; 2.07 A; B/P=1-261 PDB 5LF7; X-ray; 2.00 A; B/P=1-261 PDB 5T0C; EM; 3.80 A; AI/BI=2-261 PDB 5T0G; EM; 4.40 A; I=2-261 PDB 5T0H; EM; 6.80 A; I=2-261 PDB 5T0I; EM; 8.00 A; I=2-261 PDB 5T0J; EM; 8.00 A; I=2-261 PDBsum 4R3O; -; . PDBsum 4R67; -; . PDBsum 5A0Q; -; . PDBsum 5GJQ; -; . PDBsum 5GJR; -; . PDBsum 5L4G; -; . PDBsum 5LE5; -; . PDBsum 5LEX; -; . PDBsum 5LEY; -; . PDBsum 5LEZ; -; . PDBsum 5LF0; -; . PDBsum 5LF1; -; . PDBsum 5LF3; -; . PDBsum 5LF4; -; . PDBsum 5LF6; -; . PDBsum 5LF7; -; . PDBsum 5T0C; -; . PDBsum 5T0G; -; . PDBsum 5T0H; -; . PDBsum 5T0I; -; . PDBsum 5T0J; -; . ProteinModelPortal P25789; -; . SMR P25789; -; . BioGrid 111658; 102; . DIP DIP-29365N; -; . IntAct P25789; 33; . MINT MINT-5002513; -; . STRING 9606.ENSP00000044462; -; . BindingDB P25789; -; . ChEMBL CHEMBL2364701; -; . MEROPS T01.973; -; . iPTMnet P25789; -; . PhosphoSitePlus P25789; -; . SwissPalm P25789; -; . BioMuta PSMA4; -; . DMDM 130861; -; . UCD-2DPAGE P25789; -; . EPD P25789; -; . MaxQB P25789; -; . PaxDb P25789; -; . PeptideAtlas P25789; -; . PRIDE P25789; -; . TopDownProteomics P25789-1; -. [P25789-1]; . DNASU 5685; -; . Ensembl ENST00000044462; ENSP00000044462; ENSG00000041357. [P25789-1]; . Ensembl ENST00000413382; ENSP00000402118; ENSG00000041357. [P25789-2]; . Ensembl ENST00000559082; ENSP00000453887; ENSG00000041357. [P25789-1]; . GeneID 5685; -; . KEGG hsa:5685; -; . UCSC uc002bdu.5; human. [P25789-1]; . CTD 5685; -; . DisGeNET 5685; -; . GeneCards PSMA4; -; . HGNC HGNC:9533; PSMA4; . HPA CAB004973; -; . HPA HPA055466; -; . HPA HPA060613; -; . MIM 176846; gene; . neXtProt NX_P25789; -; . OpenTargets ENSG00000041357; -; . PharmGKB PA33878; -; . eggNOG KOG0178; Eukaryota; . eggNOG COG0638; LUCA; . GeneTree ENSGT00550000074827; -; . HOGENOM HOG000091085; -; . HOVERGEN HBG003005; -; . InParanoid P25789; -; . KO K02728; -; . OMA CNEKQRY; -; . OrthoDB EOG091G0F2L; -; . PhylomeDB P25789; -; . TreeFam TF106209; -; . Reactome R-HSA-1169091; Activation of NF-kappaB in B cells; . Reactome R-HSA-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; . Reactome R-HSA-1236974; ER-Phagosome pathway; . Reactome R-HSA-1236978; Cross-presentation of soluble exogenous antigens (endosomes); . Reactome R-HSA-174084; Autodegradation of Cdh1 by Cdh1:APC/C; . Reactome R-HSA-174113; SCF-beta-TrCP mediated degradation of Emi1; . Reactome R-HSA-174154; APC/C:Cdc20 mediated degradation of Securin; . Reactome R-HSA-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; . Reactome R-HSA-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; . Reactome R-HSA-180534; Vpu mediated degradation of CD4; . Reactome R-HSA-180585; Vif-mediated degradation of APOBEC3G; . Reactome R-HSA-187577; SCF(Skp2)-mediated degradation of p27/p21; . Reactome R-HSA-195253; Degradation of beta-catenin by the destruction complex; . Reactome R-HSA-202424; Downstream TCR signaling; . Reactome R-HSA-211733; Regulation of activated PAK-2p34 by proteasome mediated degradation; . Reactome R-HSA-2467813; Separation of Sister Chromatids; . Reactome R-HSA-2871837; FCERI mediated NF-kB activation; . Reactome R-HSA-349425; Autodegradation of the E3 ubiquitin ligase COP1; . Reactome R-HSA-350562; Regulation of ornithine decarboxylase (ODC); . Reactome R-HSA-382556; ABC-family proteins mediated transport; . Reactome R-HSA-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA; . Reactome R-HSA-4608870; Asymmetric localization of PCP proteins; . Reactome R-HSA-4641257; Degradation of AXIN; . Reactome R-HSA-4641258; Degradation of DVL; . Reactome R-HSA-5358346; Hedgehog ligand biogenesis; . Reactome R-HSA-5362768; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; . Reactome R-HSA-5607761; Dectin-1 mediated noncanonical NF-kB signaling; . Reactome R-HSA-5607764; CLEC7A (Dectin-1) signaling; . Reactome R-HSA-5610780; Degradation of GLI1 by the proteasome; . Reactome R-HSA-5610783; Degradation of GLI2 by the proteasome; . Reactome R-HSA-5610785; GLI3 is processed to GLI3R by the proteasome; . Reactome R-HSA-5632684; Hedgehog 'on' state; . Reactome R-HSA-5658442; Regulation of RAS by GAPs; . Reactome R-HSA-5668541; TNFR2 non-canonical NF-kB pathway; . Reactome R-HSA-5676590; NIK-->noncanonical NF-kB signaling; . Reactome R-HSA-5678895; Defective CFTR causes cystic fibrosis; . Reactome R-HSA-5687128; MAPK6/MAPK4 signaling; . Reactome R-HSA-5689603; UCH proteinases; . Reactome R-HSA-5689880; Ub-specific processing proteases; . Reactome R-HSA-68827; CDT1 association with the CDC6:ORC:origin complex; . Reactome R-HSA-68949; Orc1 removal from chromatin; . Reactome R-HSA-69017; CDK-mediated phosphorylation and removal of Cdc6; . Reactome R-HSA-69229; Ubiquitin-dependent degradation of Cyclin D1; . Reactome R-HSA-69481; G2/M Checkpoints; . Reactome R-HSA-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; . Reactome R-HSA-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint; . Reactome R-HSA-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; . Reactome R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation; . ChiTaRS PSMA4; human; . GeneWiki PSMA4; -; . GenomeRNAi 5685; -; . PRO PR:P25789; -; . Proteomes UP000005640; Chromosome 15; . Bgee ENSG00000041357; -; . CleanEx HS_PSMA4; -; . ExpressionAtlas P25789; baseline and differential; . Genevisible P25789; HS; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA; . GO GO:0005654; C:nucleoplasm; TAS:Reactome; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0000932; C:P-body; ISS:UniProtKB; . GO GO:0000502; C:proteasome complex; IDA:UniProtKB; . GO GO:0005839; C:proteasome core complex; ISS:UniProtKB; . GO GO:0019773; C:proteasome core complex; alpha-subunit complex; IEA:InterPro GO GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW; . GO GO:0031145; P:anaphase-promoting complex-dependent catabolic process; TAS:Reactome; . GO GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; TAP-dependent; TAS:Reactome GO GO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome; . GO GO:0000165; P:MAPK cascade; TAS:Reactome; . GO GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:Reactome; . GO GO:0010972; P:negative regulation of G2/M transition of mitotic cell cycle; TAS:Reactome; . GO GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome; . GO GO:0038061; P:NIK/NF-kappaB signaling; TAS:Reactome; . GO GO:0090263; P:positive regulation of canonical Wnt signaling pathway; TAS:Reactome; . GO GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition; TAS:Reactome; . GO GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; TAS:Reactome; . GO GO:0016579; P:protein deubiquitination; TAS:Reactome; . GO GO:0000209; P:protein polyubiquitination; TAS:Reactome; . GO GO:0006521; P:regulation of cellular amino acid metabolic process; TAS:Reactome; . GO GO:0043488; P:regulation of mRNA stability; TAS:Reactome; . GO GO:0061418; P:regulation of transcription from RNA polymerase II promoter in response to hypoxia; TAS:Reactome; . GO GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome; . GO GO:0002223; P:stimulatory C-type lectin receptor signaling pathway; TAS:Reactome; . GO GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome; . GO GO:0055085; P:transmembrane transport; TAS:Reactome; . GO GO:0033209; P:tumor necrosis factor-mediated signaling pathway; TAS:Reactome; . GO GO:0016032; P:viral process; IEA:UniProtKB-KW; . GO GO:0060071; P:Wnt signaling pathway; planar cell polarity pathway; TAS:Reactome Gene3D 3.60.20.10; -; 1; . InterPro IPR029055; Ntn_hydrolases_N; . InterPro IPR000426; Proteasome_asu_N; . InterPro IPR016050; Proteasome_bsu_CS; . InterPro IPR023332; Proteasome_suA-type; . InterPro IPR001353; Proteasome_sua/b; . Pfam PF00227; Proteasome; 1; . Pfam PF10584; Proteasome_A_N; 1; . SMART SM00948; Proteasome_A_N; 1; . SUPFAM SSF56235; SSF56235; 1; . PROSITE PS00388; PROTEASOME_ALPHA_1; 1; . PROSITE PS51475; PROTEASOME_ALPHA_2; 1; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
• World-2DPAGE Repository - A public repository for gel-based proteomics data linked to protein identification published in the literature.
• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

[Home]